COMMON PATHOGENETIC MECHANISMS AND THERAPEUTIC INTERVENTIONS IN ASSOCIATED DEGENERATIVE DISEASES
Abstract:
Specialized data indicate an increased incidence and frequent association of degenerative
diseases which cannot be attributed solely to old age, but which can be explained by pathogenic
mechanisms common to these diseases. Current research suggests that metabolic syndrome (MS) and
atherosclerosis (ATS) is associated with osteoporosis (OP) and favours the progression of osteoarthritis
(OA). Specialized literature considers MS as the connecting element. Systemic inflammation plays an
important part, being essential in the pathogenesis of degenerative diseases. Optimal therapy should act
simultaneously at both cardiovascular and skeletal level, current research being focused on this.
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