FREQUENCY CORRELATIONS BETWEEN THE NEUROLOGICAL AND THE EPILEPTIC ENCEPHALOPATHY SYNDROMES
Abstract:
Objective of the study: Based on the observations made on a period of 10 years regarding the most common form of epileptic encephalopathy (EE), namely, the West syndrome (WS), the Lennox- Gastaut syndrome (LGS), or the epileptic encephalopathy continuum form (EEC), LGS derived from WS (WS-LGS), we found a statistically significant association frequency between the hypotonic forms of cerebral palsy (CP) and LGS and between the spastic forms of CP and WS respectively. Materials and methods: The study comprised a group of 30 patients, aged between 2 months and 6 years old. Two patients were diagnosed with other forms of EE (Dravet syndrome and Landau-Kleffner syndrome), the rest of 28 with the above mentioned forms, as follows: 12 with WS, 8 with LGS and 8 with WS-LGS. The patients were included in the study based on the inclusion criteria. They benefited from general examination, neurological and psychiatric examinations, blood tests, EEG records, imagistic investigation as well as optic fundus examination. Results: After the application of the specific statistical methods, a close correlation with significant values of the parameter p has resulted, representing the association between the hypotonic and spastic forms of PC and the most common forms of EE (SW, SLG and SW-SLG). Also, significant frequency correlations were revealed between psychomotor retardation or regression and the syndromes listed. Conclusions: Although EE is defined as a heterogeneous group of entities, with well-defined individual characteristics, in addition to some common characteristics such as: polymorphous character of the seizures, resistance of seizures to treatment and variability of EEG patterns, we can add the identified neurological syndromes and their association in statistically significant proportions with WS, LGS and WS-LGS.
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