BASIC PRINCIPLES OF PHOTODYNAMIC THERAPY IN DERMATO-ONCOLOGY
Abstract:
Photodynamic therapy (PDT) is a modern procedure used in dermatology mainly in the treatment of cutaneous malignant tumours (e.g. basal cell carcinoma, squamous cell carcinoma, Kaposis’s sarcoma, mycosis fungoides) and premalignant lesions (e.g. actinic keratoses, Bowen’s disease, dysplasia and erythroplasia of oral mucosa, erythroplasia of Queyrat). The procedure requires a photosensitiser (PS) able to be selectively accumulated in the tumoral tissue and a light source capable of emitting radiation of an appropriate wavelength in order to activate the photosensitiser. This paper aims at reviewing the basic principles of PDT and the criteria for choosing the photosensitiser, the light source and the adequate values of the physical parameters used in order to obtain optimal therapeutic results with minimal adverse reactions in dermato-oncologic PDT.
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