STRUCTURAL BONE CHANGES IN THYROID DISORDERS PATHOLOGY
Abstract:
Thyroid hormones represented by triiodothyronine (T3), reverse triiodothyronine (T3) and tetraiodothyronine (thyroxine - T4) are important homeostatic regulators of bone metabolism. They are converted into active and inactive products by the 3 iodothyronin deiodinase D1, D2, D3, providing control tissue and cellular activity accomplished by the thyroid hormones and allow the body to adapt to various pathological changes. Thyroid hormone action on target cells is achieved through their receptors - TRα (α1, α2, α3) and TRβ (β1 and β2). Thyroid disorders affect bone remodelling cycle, either by variations of the circulating serum thyroid hormone levels, or because of the replacement or suppressive therapy with levothyroxine.
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