SENSITIVITY TO ANTIBIOTICS OF STRAINS OF STAPHYLOCOCCUS AUREUS ISOLATED FROM GENITAL INFECTIONS
Abstract:
Objectives: Genital infections caused by Staphylococcus aureus are common in medical practice and therefore, knowing the resistance phenotypes, namely the sensitivity to antibiotics of the circulating strains, as well as the emergence of methicillin-resistant strains, is a major goal motivating this study to start an appropriate early therapy. Material and method: I studied the antibiotic sensitivity of 420 strains of Staphylococcus aureus isolated from vaginal secretions during the period June 2010 - December 2011. The strains were isolated and identified in the laboratory of Filantropia Hospital of Craiova. The isolates were from patients hospitalized in the Department of Obstetrics and Gynaecology I of the Filantropia Hospital of Craiova. Specimens were seeded on selective and nonselective culture media and the identification was based on culture and morpho-dyeing characteristics, on the presence of coagulase and on biochemical properties. Antibiotic susceptibility testing was performed by two methods: diffusimetric - Kirby-Bauer and the determination of minimum inhibitory concentrations between two break points. Results and discussions: Of the 420 studied strains, 121 (28.8%) were methicillin-resistant, and 299 (71.2%) methicillin-sensitive. The tested strains showed reduced susceptibility to macrolides and lincosamides, the dominant resistance phenotype was not inducible. Regarding aminoglycosides, 38.09% of the analyzed strains were resistant to kanamycin, 13.09% to tobramycin, and 10.95% to gentamicin. The strains showed high resistance to tetracycline (45.95%), relatively low resistance to ciprofloxacin (10.95%) and low resistance to trimethoprim-sulfamethoxazole (3.09%). Conclusions: Methicillin-resistant strains represented 28.8% of the tested strains. All strains tested were sensitive to vancomycin and linezolid. In case of drug-resistant strains, trimethoprimsulfamethoxazole may be a therapeutic option.
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