OXIDATIVE STRESS IN PREGNANTWOMEN WITH GINGIVITIS AND DENTAL CAVITIES
Abstract:
Introduction: ROS production is inevitable in all aerobic organisms including in the human body which posses a complex antioxidant defence system. There is a balance between ROS and antioxidants. If this balance is disrupted in favour of ROS, an oxidative stress situation is created.(20) Purpose: The aim of this study was to evaluate the oxidative stress markers in serum and saliva of pregnant women with gingivitis and dental caries and to investigate the use of simple methods such as the determination of some antioxidants such as ceruloplasmin and uric acid for the clinical monitoring of the dental diseases and treatment. Materials and methods: Our research was carried out on 27 normal pregnant women aged between 18 and 39 years-old, in the fifth to ninth month of pregnancy, selected among the patients attending the Obstetrics and Gynaecology Clinics of Oradea. The results were compared with a control group matched with the study groups in terms of age, BMI, blood pressure. For proving the oxidative stress, we established the level of malondialdehyde using a method with thiobarbituric acid (TBA) and the level of ceruloplasmin with the Ravin method. The supplementary measurements such as uric acid, iron and CRP were done on HITACHI 912 Roche Diagnostics and using reagent Greiner Diagnostic, Germany. Results and discussions: The salivary MDA was higher in both studied groups compared to the reference one. We found the ceruloplasmin concentration in saliva lower in pregnant women with dental caries or with gingivitis in comparison to the control group. No significant differences were registered between the control group and pregnant women in salivary and serum uric acid concentration. CRP was immeasurable in all saliva samples, the values obtained were below the analytical range (<0.8mg/l). Conclusions: The indicators of oxidative aggression may provide a tool for monitoring the oral health of the pregnant women.
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