TSH INFLUENCE ON BONE MINERAL DENSITY IN DISTHYROIDIES
Abstract:
Thyroid disorders have a negative impact on bone metabolism; they influence bone remodelling cycle, either by changes in the circulating serum levels of the thyroid hormones, or as a result of the substitution or suppressive therapy with levothyroxine. Osteoporosis, considered a public health problem, is defined as a skeletal disease characterized by low bone strength due to the decreased bone mass and compromised bone quality. The study aims at analysing the serum variations of TSH, in the sense of increasing and decreasing its values, on bone mineral density; according to recent studies, it has been developed the idea that TSH is an important negative regulator of bone turn-over, its direct effect on bone mineral density, on formation and bone resorption indicators, being independent of thyroid hormone concentration. We analyzed a total of 650 women with and without thyroid pathology, aged between 50-70 years old, divided into three groups and three age groups. Low bone mineral density was associated both in hypothyroidism and in hyperthyroidism.
full text article in Romanian (.RO) |
full text article in English (.EN) |