HUMAN FIBRONECTIN
Abstract:
Mechanisms of premature birth do not differ fundamentally from the physiological mechanisms of birth, being involved in time-immuno-endocrine system of the load and the axis of the hypotalamo-pituitary-maternal and fetal suprarenal, limiting the cost of biological aggression. Risk factors of premature birth are both maternal and fetal and can be considered aggressors triggering mechanisms of fetal and metarnal defence and may lead to immature delivery. In interpreting the causes of premature birth, human fibronectin biomarker may be valuable. If you account for the many cellular changes that occur during pregnancy, fibronectin is involved in processes of cellular adhesion, migration and cellular differentiation, interaction matrix-cytoskeletal, phagocytosis, in the processes of hemostasis, wound healing, and healing in burn softening and immunological processes and malignant transformation. Mother’s pre- pregnancy pathology and pathology due to pregnancy lead to the change of values of fibronectin. Human fibronectin may be a biochemical parameter of prediction, diagnosis, evolution and treatment monitoring even of premature birth by dosing the proper interpretation of the dynamic and determined values, knowing its molecular behaviour.
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