THE EFFECTS OF PHOTODYNAMIC THERAPY IN BIOLOGICAL SYSTEMS
Abstract:
Photodynamic therapy (PDT) is a recent acquisition in the treatment of cutaneous premalignant and malignant lesions, based upon the administration or induction of the synthesis of a photosensitizer in the tumoral tissue, followed by the illumination of the target area using a radiation with an adequate wavelength. This paper aims to review the main molecular, cellular and systemic mechanistic aspects involved in the in vivo effects of PDT, with emphasis on apoptosis and autophagy induction in tumoral cells, local vascular destruction and immune response alteration.
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