A POSSIBLE RARE COMPLICATION OF BORTEZOMIB TREATMENT: ACUTE PANCREATITIS
Abstract:
Bortezomib is a chemotherapy drug which changed radically the treatment response and the prognosis of the patients with multiple myeloma. Besides the well-known side effects (among which fatigue, gastrointestinal, hematologic, and cardiac events, peripheral polyneuropathy), there are also rare adverse effects such as acute pancreatitis. We present the case of a patient of 72 years old, who, during the treatment with bortezomib accompanied by corticosteroids, after an episode of paroxysmal atrial fibrillation, has developed, at the next cycle, abdominal pain, nausea, vomiting, bloating and elevated serum and urine amylases, without X-ray computed tomography noticeable changes, except for a thin blade of fluid in Douglas space. The evolution was favourable after giving up bortezomib and with conservative treatment for its digestive disorder. This case is discussed in comparison with others, similar in literature.
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