EVALUATION OF INHALED DRUG DEPOSITION DURING AN ASTHMA ATTACK USING A STOCHASTIC LUNG MODEL
Abstract:
Objective: The objective of this study is to use a computerized lung model to quantify the deposition of inhaled drug particles in bronchial generations 9-16, during a severe asthma attack. Material and methods: The deposition of 1–6 μm particles in a healthy individual and during a severe asthma attack were modelled using a stochastic lung model and respiratory parameters characteristic for the two conditions. A second series of simulations were carried out using identical respiratory parameters. Results: Deposition fractions in generations 9–16 were significantly higher during the asthma attack in both series of simulations, being 100% higher for all particle sizes when using identical breathing parameters. Conclusions: Our results suggest that the deposition of inhaled particles during an asthma attack can present significant differences compared to a healthy individual, regardless of the respiratory parameters.
full text article in Romanian (.RO) |
full text article in English (.EN) |