DRUG INTERACTIONS IN CARDIAC TRANSPLANT PATIENTS - THERAPEUTIC STRATEGIES. EXPERIENCE OF TÎRGUMUREŞ TRANSPLANT CENTRE
Abstract:
The treatment of co-morbidities in the patients with heart transplant imposes restrictions or dose adjustment of calcineurin inhibitors, especially when taken with certain medications of CYP3A4- dependent metabolism. In case of administrating CYP3A4 inhibitors antibiotics (macrolides, fluoroquinolones) or inducers (rifampicine), blood concentrations should be monitored daily and made immediate adjustments in dosage. Hypertension and diabetes treatment should take into consideration the same principles. Administration of drugs with renal pharmacotoxicological tropism must consider their additive nephrotoxicity with immunosuppressive medication. The article presents the experience of cardiac transplantation centre of Tîrgu-Mureş on 35 transplanted patients during the period 1999-2011.
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