MICROBIOLOGICAL STUDY OF URINARY CALCULI IN PATIENTS WITH URINARY INFECTIONS
Abstract:
Purpose: the investigation of the urinary calculi bacteriology in relation to urinary tract infection, the study of the role of urinary tract infection in urolithiasis and the study of the antimicrobial sensitivity pattern of bacteria isolated from urine and calculi specimens. Material and methods: urine samples and urinary calculi originating from 320 patients were processed. Bacteriological study was conducted on pre-operative urine and operated renal calculi. The isolated organisms were identified by standard techniques and the antibiotic susceptibility was performed according to CLSI standards. Results: a number of 252 bacterial strains were isolated from urocultures and 188 from urinary calculi. Escherichia coli was the most frequent isolated species both from urine and urinary calculi. The comparative antibiotic resistance analysis of the isolated strains from urine and calculi showed a lower susceptibility to most of the tested antibiotics for the bacterial strains isolated from urinary calculi. Conclusions: the preponderant etiology of urinary infections in patients with urolithiasis was given by E. coli, Proteus spp., Enterococcus spp. and Pseudomonas aeruginosa. The preponderant microorganisms found in calculi were: E. coli, P. aeruginosa, Enterococcus spp. and Proteus spp. There is a statistically significant association regarding the presence of urinary calculi and the development of urinary infections. Bacterial isolates from urinary calculi were less sensitive to most of the tested antibiotics than the isolates from uroculture.
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