POLYNUCLEOTIDES VERSUS SODIUM HYALURONATE IN THE LOCAL TREATMENT OF KNEE OSTEOARTHRITIS
Abstract:
We conducted a randomized, double-blind clinical trial to assess the efficacy of intra-articular injections of polynucleotides versus hyaluronan in patients with symptomatic knee osteoarthritis. The 30 patients enrolled were randomized in two groups and received 3 intra-articular knee injections at 1 week intervals with either polynucleotides (CondrotideTM, n=15) or hyaluronan (Synocrom®, n=15). The patients were followed for 3 months after the end of treatment, with clinical evaluation before administering the first injection and then at 4, 8 and 16 weeks afterward. We used the Visual Analog Scale for pain assessment and calculated the Knee Osteoarthritis Outcome Score and Knee Society Scores (knee and functional). We found a statistically significant decrease of pain levels in both groups, with Knee Society Scores showing a statistically significant improvement only in the polynucleotide group. We concluded that the use of polynucleotide injections in the treatment of knee arthritis is a viable option in symptomatic cases.
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