THE INFLUENCE OF ANGIOTENSIN CONVERSION ENZYME INHIBITORS (ACEI) AND OF ANGIOTENSIN II RECEPTOR ANTAGONISTS (ARA) OVER THE AORTIC STIFFENING INDICES (PWVAo, AIxAo) IN ARTERIAL HYPERTENSION OF THE ELDERLY
Abstract:
Clinical research data proved that isolated systolic arterial hypertension situations or those with high pulse pressure (PP), found more frequently in the older patients, are characterized by a process of stiffening of the large vessels, due to a degradation of the elastic tissue found in the medium tunica, which is then replaced by collagen fibres.(1,2) From a haemodynamic point of view, the stiffening of the Aorta leads to an increase of the Pulse Wave Velocity (PWV) and to an increase of the Augmentation Index (AIx) at the central level.(3,4) The new guides of the Arterial Hypertension European Society concerning the management of hypertension allotted separate subchapters to the central arterial hypertension, the vascular complications of arterial hypertension, and especially to the stiffening of the large vessels. The evaluation of the hypertensive patient should include PWV, wherever possible.(5)
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