Myo1H GENE SINGLE NUCLEOTIDE POLYMORPHISM rs10850110 AND THE RISK OF MALOCCLUSION IN THE ROMANIAN POPULATION
Abstract:
Background. The Matrilin-1 gene is thought to be involved in the formation of the filamentous network of the cartilage’s extracellular matrix and implicitly in the formation of the mandibular condyle cartilage, very important in different malocclusions. Objectives. The purpose of this study was the association of the marker Myo1H (rs10850110) with malocclusions. Methods. The sample comprises 47 patients with different malocclusions. The control group included 11 individuals. Cephalometric measurements were performed. The genotyping was done by sequencing. Results. Significant differences concerning allele and genotype distribution were observed between different malocclusions and the control group. The genotypes were distributed in the population according to Hardy-Weinberg equilibrium. Conclusions. Our findings are in agreement with other studies that emphasize the importance of the Myo1H gene in the determination of Class I, II and especially Class III phenotypes.
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