Multiple relapses characterise the course of illness in most patients with schizophrenia. Identifying the patients at risk of relapse is necessary and sometimes, it may be difficult for the clinician. This study aimed at identifying the risk factors associated with the chronic course and multiple relapses in children diagnosed with Acute Psychotic Disorder, Schizophrenia or Schizoaffective disorder hospitalized in Pediatric Psychiatry Clinic, Cluj-Napoca, between January 2005 - December 2009. It is a clinical, analytical, observational, retrospective study. The patients were divided into two groups: a group with a favourable course of disorder, without relapses under treatment and a group with chronic course, with frequent relapses under treatment. The study confirmed statistically significant correlation between the presence of family history of schizophrenia, personal history of premorbid neurological disorders and dysfunctional family, and the severe course of psychotic disorders in children and adolescents.