EVALUATION THROUGH ARTERIOGRAPHY MEASUREMENTS OF THE EFFECTS OF IECA+D TREATMENT COMPARED TO THE BRA+D ONE ON THE DETERMINING PARAMETERS OF THE ARTERIAL FUNCTION (SBPAO, PWVAO, AIXAO) IN THE ELDERLY
Abstract:
Clinic research has shown that isolated systolic arterial hypertension (HTAS) more frequently encountered in the elderly, is characterised by a process of stiffening of the big vessels due to the deterioration of the elastic tissue from the medium tunic replaced by collagen fibres.(1,2) From a hemodynamic point of view, the stiffening of the aorta leads to a growing of the pulse wave velocity (PWV) and of the augmentation index (AIx) at the central level.(3,4) The vascular rigidity (the stiffness) appears before atherosclerosis irrespective of the classical risk factors. The examination of the arterial stiffness has been included in the ESH/ESC 2007 Guides regarding the management of the arterial hypertension.(5) It has been demonstrated that the medicines with an effect on the rennin-angiotensinaldosterone system, in other words IECA and BRA, are in fact the most efficient medicine class in the case of lowering the arterial stiffness. More than that, in some cases this effect is more outstanding than the effect of lowering the arterial tension.(6)
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