TRANSIENT APLASTIC CRISIS IN THE EVOLUTION OF ACUTE PARVOVIRUS B19 INFECTION IN A PATIENT WITH IRON-DEFICIENCY ANEMIA: A CASE REPORT
Abstract:
The Parvovirus B19 infection is responsible in children for the fifth disease, also called erythema infectiosum or the slapped-cheek disease. In patients with chronic hemolytic anemia such as sickle-cell disease, spherocytosis, pyruvate kinase deficiency or beta-thalassemia, the parvovirus B19 infection may induce transient aplastic crisis diagnosed by the decreasing of hemoglobin with more than 2g/dL or reticulocytes under 0.2%. The infection in immunocompetent adults is rarely associated with rash, 80% of women present pain in the inter-phalangeal joint of the hands, fist, elbow, knee, occasionally in the cervical and lumbar region and hips, pain that lasts for 2-4 weeks. The Parvovirus B19 infection associated with the first semester of pregnancy may induce miscarriage in 5-10% of cases and hydrops fetalis in the second and third trimester In immunocompromised patients, the parvovirus B19 causes a persistent infection. We report a case of a female patient with aplastic anemia associated with iron-deficiency anemia in the context of parvovirus B19 infection.
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