DUCTAL ADENOCARCINOMA OF THE PROSTATE: CASE REPORT AND DIFFERENTIAL DIAGNOSTIC CONSIDERATIONS
Abstract:
Prostatic ductal adenocarcinoma is a rare subtype of cancer of the prostate. Recognition of
this malignant neoplasia is important because of its particularities: diagnosis in advanced stages,
normal or low serum prostate specific antigen (PSA) and poor prognosis. It also shows no response to
hormonal therapy, such as acinar adenocarcinomas and requires early aggressive treatment. We present
the case of a male patient who suffered a transurethral prostatic resection surgery. Histopathological
examination revealed a malignant neoplastic proliferation with predominantly papillary architecture
composed of conjunctive-vascular cores lined by tall cylindrical epithelium with atypical pleomorphic
nuclei and mitoses. Immunohistochemical examination highlighted the primary nature of tumour and
origin in the prostatic ducts, excluding several primary or secondary neoplastic lesions.
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