THE LEVEL OF MATRIX METALLOPROTEINASE-8 IN THE GINGIVAL CREVICULAR FLUID – DIAGNOSTIC AND PROGNOSTIC IMPLICATIONS IN PERIODONTAL DISEASE
Abstract:
The biochemical composition of healthy and diseased periodontal connective tissues is
determined by the extension of the degradation and synthesis of matrix components. Objective: The aim
of our study was to comparatively assess the level of matrix metalloproteinase-8 (MMP-8) in the
gingival crevicular fluid (GCF) in patients with periodontal disease with the levels found in patients free
of periodontal disease. Materials and methods: The filter paper intended for sampling was placed to the
maximum depth of the gingival sulcus. To perform the ELISA test, the GCF samples were assessed in a
dilution of 1:20. Results: There was a statistically significant difference between the concentration levels
of MMP-8 in the GCF in the group of patients with chronic periodontitis or gingivitis and the subjects in
the control group. Conclusion The concentration of MMP-8 in GCF may be a particularly useful
indicator for monitoring the therapeutic response in periodontal disease.
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