THE IMPORTANCE OF THE HEREDITARY RISK FACTORS IN THE NEOPLAZIC DISEASE
Abstract:
During lifetime, cancer risk is an individual risk and depends of our genetic luggage. Breast cancer is an example in which immediate relatives may have a higher risk of breast cancer or other types of cancer. Sometimes the increased risk may be due to a genetic mutation. BRCA1 and BRCA2 are examples of genetic mutation that give rise to the increased risk of breast cancer. Women with these mutations also have significantly higher risk of developing ovarian cancer. Most of the familial cancers are multi-factorial and most of the times, there are no demonstrable genetic markers or patterns. The pattern of familial clustering occurs more in certain cancer types, such as: breast cancer, colon cancer, and ovarian cancer. Genetic testing is now possible and important for assessing the risk of cancer.
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