NITRIC OXIDE IN SEPSIS FROM DEFICIENCY TO OVERPRODUCTION
Abstract:
The presence of NO in blood is important to regulate the vasomotor tonus and the blood flux, and to inhibit the adhesion of leukocytes and of plakets and to modulate the coagulation activity. The proofs suggest that sepsis is associated with: rapid lowering of the ecNOS function with altered relaxation derived from endothelium; increase of the iNOS function which is delayed with a few hours, associated with a modified response of the smooth muscle to vasoconstrictors and vasoplegia
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