ISCHEMIC PRECONDITIONING FROM MECHANISMS TO THERAPEUTICAL POSSIBILITIES
Abstract:
Ischemic preconditioning (IPC) is a powerful endogenous form of cardioprotection of myocardial ischemia. The protective effect of ischemic preconditioning consists in diminishing the negative consequences of ischemia. Ischemic preconditioning increases myocardial resistance to ischemia, resulting in increasing the available time for applying the antiischemic therapy. During coronary permanent occlusion, or in severe permanent ischemia, preconditioning is inefficient and does not involve cardioprotection. Opening of the mitochondrial KATP channels seems to play a central part in the protective mechanism of preconditioning. Nicorandil, a selective mitochondrial KATP channel opener, has been extensively used in many experimental and clinical studies with very promising results.
full text article in English (.EN) |