IMMUNOGLOBULINS TREATMENT IN THE NEUROLOGICAL PATHOLOGY
Abstract:
Soon after the description of the immunomodulatory effect of IVIg, neuroimmunological diseases were also treated with IVIg. Guillain-Barre syndrome (GBS), chronic demyelinating polyneuropathy (CIDP), multifocal motor neuropathy (MMN), myasthenia gravis, paraneoplastic neurologic syndromes, multiple sclerosis, were successfully treated with IVIg. Immunoglobulins can modulate an immune reaction at the level of T cells, B cells, and macrophages, interfere with antibody production and degradation, modulate the complement cascade, and have cytokine network effect. However, the precise mechanism of action is not clear yet. In general, IVIg therapy side effects are usually minor and self-limiting. This therapy seems to be effective and safe for a variety of neuroimmune-mediated diseases, too.
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