THE EFFECTS OF DIOVAN AND NEBILET TREATMENT ON DIASTOLIC DYSFUNCTION IN HYPERTENSIVE PATIENTS
Abstract:
Objective: The aim of this study is to evaluate the effects of the treatment with the angiotensin receptor blocker - Diovan and of the cardioselective beta-blocker - Nebilet on the diastolic dysfunction, in grade II and III hypertensive patients, with diastolic dysfunction, echocardiographically detected. Materials and Methods: A prospective, clinical study was conducted on a six month follow–up period. The hypertensive patients were randomly assigned to either Diovan (80-160mg/day) or Nebilet (5-10mg/day). Results: 80 patients were enrolled in the study, 42 of them in Diovan group and 38 in Nebilet group. E/A ratio mean, significantly increased in both groups from baseline values (p<0,05), mean deceleration time (DT) and mean isovolumetric relaxation time (IVRT) significantly decreased from baseline values, in both treatment groups, p < 0,05). Conclusions: After 6 months of treatment, both Diovan and Nebilet improved left ventricular transmitral flow, by improving transmitral flow parameters, in patients with grade II and III hypertension and diastolic dysfunction.
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