GROWTH AND DEVELOPMENTAL DISORDERS. HORMONALLY CONDITIONED STATURAL RETARDATION
Abstract:
Hormonally conditioned statural retardation
represents almost 10% of the total of growth disorders. In
etiology, disorders of the following hormones are
incriminated: somatotrope, somatomedins, thyroid
hormones, insulin, vitamins of the D group, hypophysial
and vasopressin gonadotropes. The clinical aspects of the
hormonal etiology mechanism are numerous: the isolated
somatotrope deficiency brings about harmonic dwarfism
with normal sexual development, while the hypophysial
dwarfism (due to other deficiencies in the hypophysial
tropes) leads to disharmonic dwarfism with variable
obesity, genital infantilism and infertility. The lack of the
thyroid hormones leads to the disharmonic dwarfism with
embryo-fetal anthropometric proportions, mixededematous
infiltration, late puberty, cognitive
retardation. Insulin deficiency leads to dwarfism, late
osseous age and sexual maturity. Precocious puberty (due
to somatotropes) produces the early closure of the growth
cartilages. Its evolution starts from the small Herculetype
child to the hypostatural adult.
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