THE ROLE OF IL-6 AND ERYTHROPOIETIN IN CHILDREN WITH SECONDARY THROMBOCYTOSIS IN INFECTION AND ANEMIA
Abstract:
The main regulation factor for thrombopoiesis
is thrombopoietin. A relationship between the degree of
thrombocytosis and the level of IL6 has not been
established yet. The mechanism of secondary
thrombocytosis due to iron deficiency anemia is not fully
known. A cross-reaction, due to structural similarity of
EPO and TPO, involving the c-Mpl receptor is suspected
but not yet confirmed. Method: The study is prospective,
made up of 39 children with secondary thrombocytosis,
anemia and upper respiratory infection. We determined
full blood count, platelet and erythrocyte parameters,
CRP, ESR, IL6, EPO. Conclusions: 66,66% patients had
levels of IL6 above normal. The mean value was 10,210
(std. dev. 12,7530, std. error 2,04). 15 of these patients
had CRP above normal, 18 had ESR above normal, 23
had leukocytosis, suggesting secondary thrombocytosis
due to infection. All patients with iron level below normal
values had increased levels of either EPO or IL6, most of
them with increased IL6, suggesting intra-infection cause
for anemia and regulation mechanism of erythropoiesis
that do not involve EPO.
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