CORRELATIONS BETWEEN THE LEVEL OF THE PARATHYROID HORMONE AND THE RADIOLOGICAL BONE CHANGES IN CHRONIC HAEMODIALYSIS PATIENTS
Abstract:
Renal dialysis is a procedure that is applied to
people who lost a kidney, have kidney problems due to
birth defects, or who have chronic renal failure.
Osteodystrophy caused by secondary
hyperparathyroidism in chronic renal failure is a clinical
anatomical form of renal bone disease. It derives from the
alteration of various mediators of bone metabolism,
which in physiological conditions ensure and maintain
the ratio of bone remodelling, reabsorbtion of already
formed trabeculae and mineralization of new ones, the socalled
„bone turnover”. Impairing of calcium phosphorus
balance, of vitamin D metabolism and parathyroid
function, together with changes in the skeleton, is one of
the constant manifestations of uraemia. Plasma
parathyroid hormone level is a good index of bone
remodelling. The criterion for assessing the severity of
renal osteodystrophy is the measurement of biochemical
markers of bone turn-over: PTH, serum calcium,
phosphate, alkaline phosphatase, ostecalcin.
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