NEWS IN THE CLASSIFICATION AND THE DIAGNOSIS OF CHRONIC MYELOMONOCYTIC LEUKEMIA
Abstract:
Chronic myelomonocytic leukemia (CMML) is a heterogeneous group of disorders with
features both of myelodysplasia and of myeloproliferation,some patients showing clinical and
morphologic features resembling refractory anemia with excess of blasts (RAEB) with monocytosis,and
others with leukocytosis,neutrophilia,monocytosis and splenomegaly. Some common features concerning
cytogenetic abnormalities, the pattern of the growth in cell cultures and clinical evolution contributes to
the maintenance of this nosological entity, CMML. The intrinsic differences determined at first the
separation of CMML in two forms, one named „dysplastic”, more similar with RAEB and the other
„proliferative”, closer to chronic myeloid leukemia. The World Health Organization (WHO)
classification included CMML into a new category called myelodiysplastic / myeloproliferative
disorders and defined CMML I and CMML II according to medullary and peripheral blast count.
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