CORRELATION BETWEEN THE PLASMATIC LEVEL OF THE SOLUBLE TUMOR NECROSIS FACTOR-α RECEPTOR (sTNFα-RI) AND THE PRESENCE OF ATRIAL FIBRILLATION IN PATIENTS WITH DILATED CARDIOMYOPATHY AND HEART FAILURE
Abstract:
Atrial fibrillation is the most common arrhythmia, as well as the major cardiovascular mortality and morbidity cause,the identification of new mechanisms involved in the pathogenesis of this disease being important. Tumor necrosis factor (TNF) and plasma levels of soluble tumor necrosis factor receptor I (sTNFα-RI) are elevated in patients with heart failure due to chronic inflammation, being a negative prognostic factor. Atrial fibrillation (AF), whose relationship with sTNFα-RI has been less studied, is also a negative prognostic factor. Our study is based on 54 NYHA III-IV congestive heart failure (CHF) and dilated cardiomyophaty (DCM) patients, 40 ischemic and 14 non-ischemic, 35 males and 19 females, mean age 65±10 years, ejection fraction 46.63±9.88% and NYHA class III-IV. Chronic heart failure was defined according to the European Society of Cardiology criteria. In all patients, sTNFα-RI serum value was determined using ELISA method, with normal level deemed
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