INVASIVE FUNGAL INFECTIONS. RISK FACTORS AND EVOLUTION IN PATIENTS WITH MALIGNANT HEMOPATHIES
Abstract:
Invasive fungal infections are infectious complications with an increasing incidence, raising
countless problems regarding the diagnosis and the treatment in children with malignant diseases.
Objective. The analysis of invasive fungal infections in children with malignant hemopathies. Material
and method. We underwent a retrospective analysis of invasive fungal infections on a lot of 132
patients with malignant hemopathies, treated in the Pediatric Clinic no 2 of Cluj-Napoca in the period
2001-2010. Results. The incidence of the invasive fungal infections was 9.8% of the total number of
infectious episodes. We noted correlations between invasive fungal infections, prolonged severe
neutropenia (p 0.000) and, respectively, antibiotherapy (0.000). Episodes were diagnosed as “possible”
(60.7%), “probable” (21.4%) and “proven” (17.9%). Most frequent etiologies were Aspergillus and
Candida spp. Mortality due to invasive fungal infections was of 14.3% and chemotherapy delays had a
median of 20 days. Conclusions. It is of strict necessity to introduce efficient methods of prevention,
diagnosis and treatment of invasive fungal infections in children with malignant hemopathies.
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