CHANGES IN CEREBRAL BLOOD FLOWVELOCITIES MEASURED BY DOPPLER ULTRASONOGRAPHY AFTER HYPOXIC-ISCHEMIC INJURY IN NEWBORNS
Abstract:
Perinatal hypoxic-ischemic insults may lead to significant morbidity and mortality in neonates
and infants. Because anoxic-ischemic process is related to changes in cerebral blood flow, a
hemodynamic study is required, and can guide towards early diagnosis and prognosis. The aim was to
investigate cerebral hemodynamics with Doppler-ultrasonography and search for correlations between
cerebral hemodynamic parameters and other changes in asphyxia. Material and methods: 21
asphyxiated newborns, admitted to our intensive care unit and 200 healthy ones were studied in the first
72 hours of life. Results: cerebral blood velocities were initially significantly lower in asphyxiated
infants than in control group, after 12 hours diastolic velocity increased and resistive index decreased,
and these findings remained constant after 48 hours in babies with poor outcome. Conclusions:
Doppler-ultrasonography is a reliable tool in clinician’s hands in detecting the impairment of
autoregulation due to hypoxic-ischemic injury in newborns and evaluating prognosis.
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