ASPECTS IN ACUTE PANCREATITIS ETIOPATHOGENY
Abstract:
Acute pancreatitis is characterized by the occurrence of necroinflammatory changes in the
pancreas. Three types of necrosis may be distinguished: (1) interstitial tissue necrosis, which
subsequently may also involve acinar and ductal cells, (2) ductal necrosis, and (3) acinar necrosis. The
first type of necrosis is autodigestive in nature and is typical of the most common forms of acute
pancreatitis, which are associated with alcohol, bile duct disease, metabolic conditions, and other rare
factors. Clinically, these types of pancreatitis may be either mild or severe (Atlanta classification). The
mild form is also known as edematous pancreatitis, because there is edematous swelling of the pancreas
combined with tiny foci of interstitial (fat) necrosis. Severe or necrotizing pancreatitis shows large areas
of often hemorrhagic necrosis of the pancreatic and particularly the peripancreatic tissue.
Complications of acute pancreatitis, such as pseudocyst, bleeding, and infection, determine the course of
the disease.
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