CLINICO-EPIDEMIOLOGICAL RESEARCHES ON THE USE OF THE ANTIDOTE IN ACUTE ORGANOPHOSPHATE POISONING ON PATIENTS ADMITTED IN THE MEDICAL CLINIC OF “SF. IOAN” EMERGENCY CLINIC HOSPITAL, IASI, DURING 2003-2009
Abstract:
In the present study we have analyzed the clinical evolution of the patients intoxicated with
organophosphate insecticides, depending on the prescribed treatment, being a well-known fact that the
reactivators of cholinesterase are administered only in the first 48-72 hours from the ingestion of the
toxin, while after this period there appears a dezalkylation of the complex cholinesterase –
organophosphorate substance (OPs), which triggers the irreversibility of the process of blocking the
cholinesterase. Material and method: we have analyzed retrospectively a number of 137 patients
hospitalized in the period 2003-2009. Results: all the patients were given supportive treatment and the
association of Atropine, Obidoxime (Toxogonin) and plasma was administered only for 25,5% of the
intoxications with OPs. There are no statistically significant differences between the evolution of the
patients intoxicated with OPs treated only with Atropine and those treated with Atropine and Toxogonin
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