PREDICTOR FACTORS OF THE MENOPAUSE INSTALLATION BEFORE 45 YEARS AT PATIENTSWITH AUTOIMMUNE THYROID DISEASE
Abstract:
Objectives: The aim of this study was to identify predictive factors for early menopause (EM)
to autoimmune thyroid disease patients (AITD). Material and methods: The study included 162 patients
with AITD diagnosed before 45 years. We performed univariate analysis of several independent factors
by multivariate logistic regression analysis of the factors with statistical significance (p <0.01), with a
score of predictive modeling. Results: Score EM prediction = -2.2022 x Age <35 years at the diagnosis
of AITD (1 / 0) + 1.9328 x Infertility (1 / 0) -0.3792 x Antiovarian antibodies (IU / ml), the criterion ≤ –
1.8359, sensitivity 90%, specificity 88 %, AUC - 0.91. Conclusions: Two predictors are linked AITD for
diagnosis: age <35 years which decreases the risk and infertility which increase the risk, and may have
a correlation with ovarian aging and occult ovarian failure.
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