THE REASSESSMENT OF ANTIOVARIAN ANTIBODIES TEST PERFORMANCE IN THE DIAGNOSIS OF PREMATURE OVARIAN FAILURE IN PATIENTSWITH AUTOIMMUNE THYROID DISEASE
Abstract:
Objective: To reassess the antiovarian antibodies test performance in the diagnosis of
premature ovarian failure of the patients with autoimmune thyroid disease. Material and method: The
study involved 70 patients with autoimmune thyroid disease, from which ten cases (10/70, 14.4%) were
associated with premature ovarian failure and were found to have serum antiovarian antibodies, using
as reagent a mixture of ovarian proteins; the values greater than 10 IU/mL were considered positive.
Results: Antiovarian antibodies were positive in one case (1,4%, 1/70) and was not a case of premature
ovarian failure; in the same case antinuclear antibodies were positive. Conclusions: Determination of
the circulating antiovarian antibodies as a possible predictive factor for premature ovarian failure is not
really sustained, especially because it doesn’t exist a recognized specific marker of the ovarian
autoimmunity, and the study results are statistically insignificant.
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