AN IN VITRO STUDY OF CLOTRIMAZOLE MICROSPHERES
Abstract:
This paper aims at presenting the formulation and preparation of a dosage form with slow
release (microsphere ovules) with chloramphenicol as an active substance, useful in the treatment of
vaginal infections with Candida albicans and Trichomonas vaginalis. Microspheres are solid dosage
forms of the reservoir type, formed of the particles of the active substance, in liquid or solid state,
covered in a polymeric film, which represents the microcapsule wall and in whose compositions one or
more natural or synthetic polymers are included. These microspheres have been incorporated into
suppositories through enclavation and casting. We produced three microsphere types: with sodium
alginate, chitosan, and ultrasonic produced chitosan. We then pursued the study of the release of
chloramphenicol from microcapsules incorporated in vaginal suppositories at various pH levels. The
slowest release was proved to be that of the chitosan microspheres obtained by gelification with
tripolyphosphate and syringe extrusion, as a result of the modern preparation technique.
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