STATUS OF HUMAN PAPILOMA VIRUS IN A COHORT OF ROMANIAN WOMEN
Abstract:
Cervical cancer is the fourth most frequent type of cancer in women worldwide and its
occurrence is strongly associated to high risk genotypes 16/18/31/33/35/39/45/51/52/56/58/59/66 of
human papillomavirus (HPV). This observational study aimed to investigate the status of HPV infection
in a cohort of 725 Romanian women requesting specialty services in a clinic of gynaecology from
Bucharest. In our cohort, the HPV genotype 16 was by far most frequently identified and it was followed
by genotypes 51, 31, 52 and 18 (prevalence of 37.5; 13.9; 13.4; 11.8; 10.6% respectively). Its presence
increased significantly in women having HSIL cytology, compared to cases with less severe cytology
results. We found also very low use of vaccination and HPV testing. Due to methodologic limitations,
our results cannot be generalised in the Romanian women population and further research is needed for
this purpose. However, our results suggest the need for a stronger public health approach for prevention
and control of cervical cancer in Romania
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