PARAMETERS OF CARBOHYDRATE METABOLISM IN CHILDREN WITH NON-ALCOHOLIC FATTY PANCREAS
Abstract:
The aim of the study is to establish the features of carbohydrate metabolism in children with nonalcoholic fatty pancreas disease. Materials and methods: We observed 77 children aged 7-17 years old. The pancreatic steatosis was evaluated by ultrasonography with quantitative evaluation of the ultrasonic attenuation coefficient of the pancreas using the Ultima Expert apparatus Radmir, Ukraine). Children were divided into 3 groups: 1st group - 42 children with pancreatic steatosis and obesity/overweight; 2nd group - 25 obese/overweight children without pancreatic steatosis; 3rd group - 10 children with normal weight. The blood serum insulin level was determined by immunoassay, followed by the calculation of the HOMA1-IR, HOMA-2. Results: Patients with pancreatic steatosis had significantly higher HOMA1-IR, HOMA-2 level compared to children without steatosis p<0,05). The average coefficient of ultrasound attenuation during pancreatic steatometry was significantly higher in patients with pancreatic steatosis and negatively correlated with cell sensitivity to insulin r=-0,26; p<0,05). Conclusion: The study of the HOMA1-IR, HOMA-2 index showed an increase in the secretory function of β-cells in children with pancreatic steatosis, along with a decrease in cellular sensitivity to insulin.
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