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The journal publishes original articles revealing recent research results in public health and management, review articles providingup-to-date analysis or discussion on research previously published by others, case reports describing interesting and exceptional clinical cases the authors have confronted with.

 

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Starting with issue 1/2015, Acta Medica Transilvanica journal will publish the articles in English language only.

 

Published since 1996

EPIGENETIC LANDSCAPE OF HUMAN DISEASES

Abstract:

The last years have brought profound insights into molecular mechanisms and application of epigenetics to medicine. Alteration of epigenetic profile is considered to be influential in both the normal and disease state of an organism. Various diseases, such as cancers, neuropsychiatric disease and other non-neoplastic disease are often associated with epigenetic alteration. In the light of increasing knowledge on the involvement of epigenetic factors in disease, it is now becoming apparent that epigenetic factors could be ideal therapeutic targets. In the context of the new insights of epigenetics, this review summarized the epigenetic mechanism of gene expression and the most important epigenetic pathologies.


 
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