In the last years, more and more cases of infections with bacterial strains of the Myroides genus have been presented, that have drawn the attention because of their resistance to antibiotics. Most of these occurred in the cases of the immunocompromised patients and some of them were fatal. We present a case of urinary tract infection with Myroides spp in a patient with diabetes and chronic peripheral arterial disease of the lower limbs. The patient presented himself at the emergency department with septic state, wet calcaneal gangrene extending to the lower leg of the left inferior limb and dry gangrene of the right thumb toe; subsequently, he was hospitalized in the general surgery department. Conclusions: Although Myroides spp are unusual pathogens, they can cause infections in the immunocompromised patient. Clinicians need to be familiar with these types of bacteria, which cause treatment problems due to the resistance to antibiotics.