THE INFLUENCE OF KIDNEY INJURY ON THE NON-INVASIVE ASSESSMENT OF HEPATIC INFLAMATION
Abstract:
Kidney injury plays a crucial part in the prognosis and progression of chronic hepatitis. The purpose of our study is to record the levels of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and to evaluate potential correlations between their level and altered renal function. Materials and methods: We ran a retrospective observational study based on information collected from 401 patient charts of the 1st Internal Medicine Clinic of the Emergency County Clinical Hospital Tirgu-Mures. The study was comprised of patients, based on informed consent, with recorded liver disease, with normal or diminished renal function. Results: Statistical significant difference was observed between serum AST and ALT levels and serum creatinine levels (p<0,0001). Conclusions: The serum aminotransferase levels tend to remain lower in patients with impaired renal function compared to the control group, thus raising the issue of underestimation of liver function in these patients and the need for different thresholds for AST and ALT or alternatives for hepatic inflammation quantification.
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