UNFAVOURABLE PROGNOSIS MARKERS IN THE ASSOCIATION OF TYPE I SUGAR DIABETES WITH THE CELIAC DISEASE
Abstract:
The association of celiac disease with sugar diabetes has been demonstrated by the common genetic aspect (HLA-DR3) which correlates with the serious evolution of the type I diabetes. Object and method. During 2008-2009 we have followed the quantification of the associated autoimmune phenomena through immunoenzymatic reactions on a group of 40 children with sugar diabetes of type I. Results. The immunologic markers’ prevalence was: liver-kidney anti-microsomal antibodies 2.5%, soluble liver antigen 0%, glutamic acid anti-decarboxylase antibodies 35%, anti-tyrosine phosphatase antibodies 55%, anti-insulin antibodies 50%, cytoplasmic anti-insulin antibodies 2.5%, anti-thyroglobulin antibodies 11.1%, antithyroidperoxidase antibodies 23.1% and tissular antitransglutaminase antibodies IgA 25.7%. The main associations of the found IgA tissular antitransglutaminase antibodies were with the glutamic acid anti-decarboxylase antibodies r=0.33 (p=0.027). Conclusion. Since the presence of the glutamic acid anti-decarboxylase antibodies associated with the tissular antitransglutaminase antibodies IgA, these could be used as predictive markers in the unfavorable development of the type I sugar diabetes.
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