PERITONEAL FIBRINOLYTIC ACTIVITY AND ADHESIOGENESIS
Abstract:
The triggering of the formation of adhesions is caused by the organization of the fibrin matrix, an organization that takes place during the coagulation processes when there is suppression of fibrinolysis. In this study two groups of patients are analyzed. First group was used for extract the tPA and PAI-1 from the peritoneal tissue. The second group is the control group in whose cases none of the aggression factors (traumatic, chemical, bacterial) noticed in the patients of the first group was proven to exist. The aim of this study was to evaluate the role of PAI-1 and tPA genes at peritoneal tissue level. Peritoneal tissue was obtained during surgery and we have quantified the variation of expression of PAI-1 and tPA genes. The obtained results highlight an increase of expression in PAI-1 gene and decrease of expression in tPA gene, which indicated an decrease in the fibrynolitic potential.
articol integral în limba engleză (.EN) |