PLACENTAL ENDOCRINE FACTORS INVOLVED IN INTRAUTERINE GROWTH
Abstract:
Placenta shows hormonal functions like: progestational, fetal and placental growth, regulatory. Progestational role factors are progesterone, estrogen, chorionic gonadotropic hormone (hCG), inhibin (A, B) and activin (A, B), CRH. Progestational hormones promote growth of the placental mass, allowing implantation and maintaince of the pregnancy and represent fetal substrate for fetal synthesis of glucocorticoids, mineralocorticoids, testosterone promoting growth of the alveolar cells and lobules in the breast. The placental hormones with a preponderant role in fetal growth are: HPL, HGH-V, growth factors IGF I, II. Placental Lactogen (chorionic somatotropin) (HPL / HCS-A, B) occurs in the first part of pregnancy whereas variant placental growth hormone (hGH-V) in the second part. They regulate fetal growth by sparing glucose and amino acids for the fetus, modulating the insulin resistance and mobilization of fatty acids for metabolic needs of the mother.
articol integral în limba engleză (.EN) |