ENDOCRINE FACTORS INVOLVED IN INTRAUTERINE FETAL GROWTH
Abstract:
Major fetal hormones involved in regulating fetal growth are fetal growth factors (IGF insulin-like growth factor, insulin, GH's - growth hormone) or hormones for maturation (steroid hormones, thyroid hormones and catecholamines). IGF-II are involved in early gestation, IGF-I in late gestation both growth factors regulate growth by IGF-I receptor. Insulin increases fetal secretion of IGF-I, GH determines the correct number and size of various organs without being a major determinant of growth (eg weight fetuses anencephalic / almost normal length at birth). Thyroid hormones, adrenal hormones, corticosteroid hormones have an important role in bone, lung, heart maturation.
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