GRAM-NEGATIVE BACILLI INFECTIONS IN HIV INFECTED PATIENTS
Abstract:
The epidemiology of bacterial infections during HIV (human immune deficiency virus) infection changed after the introduction of HAART (highly active antiretroviral therapy) and of the prophylaxis programmes addressing the associated infections, which led to an increased prevalence of some of them. Despite the relatively low incidence, the gram-negative bacilli (GNB) infections must be suspected in the case of bacterial complications in these patients, considering the severe potential of respiratory and systemic infections caused, and also the variable susceptibility to antibiotics. The study targets the peculiar etiologic and clinical aspects of GNB infections in seropositive patients vs. seronegative ones, the characterization of germs from the antibiotics sensitivity point of view and the connection with the severity of the immune suppression. The data are analyzed and the results are presented in a comparative manner with those obtained from non-infected HIV patients. The retrospective study supports the implication of deep immune suppression in causing the severe GNB infections, the role of HAART in preventing the respiratory complications caused by these germ and also the recommendation of the antibiotherapy uninfluenced by the seropositivity status.
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