Radical retropubic prostatectomy (RRP) has gradually become the main therapeutic method used in patients with localized prostate cancer (pT1-T2) and with a life expectancy greater than 10 years. The purpose of this study is represented by the clinical evaluation of the effectiveness of open radical retropubic prostatectomy with bilateral ilio-obturator lymph node dissection in patients with prostate cancer. We studied a group of 147 patients who underwent open radical retropubic prostatectomy for prostate cancer in localized stage between January 2008 - February 2014 The average age of patients was 61.4 years. Preoperative PSA level was between 2.3 and 19.3 ng / ml. Preoperative tumour stage was T1-T2 in 89.9% of cases and in 10.1% of cases, T3a. After puncture prostate biopsy, Gleason score revealed that 65.98% of patients had a score below 6; 23.12% of patients had a score of 7 and 10.9% of patients had a score greater than or equal to 8; 42.85% of the group received radical retropubic prostatectomy with the bilateral preservation of the neuro-vascular bundles and 14.96% received only unilateral preservation of the neuro-vascular bundle. The research has shown that open radical retropubic prostatectomy is an effective treatment with curative intent in the carefully selected patients with localized prostate cancer. This surgical procedure provides good oncological outcomes with long life expectancy, good quality of life for patients and a low incidence of complications