Minimally invasive endoscopic procedures for reno-uretheral lithiasis consist of either the anterograde approach - the percutaneous nephrolithotomy (PCNL) and antegrade ureteroscopy (US), which allows viewing the pyelocaliceal system and proximal ureter, or the retrograde approach, thus allowing the retrograte ureteroscopy. The objective of the study is to evaluate the efficacy and safety of percutaneous nephrolithotomy and ureteroscopy in clinical, technical and managerial terms in the adults with kidney stones. During 2005 and 2013, I conducted a descriptive clinical study based on the clinical and imaging parameters. The study group consisted of 1235 adult operated patients, of both genders, respectively 1251 interventions, of which PCNL 787 cases and 464 US cases. The study results demonstrate that PCNL and the AU are safe and effective having as main advantages: fragmentation and extraction of stones regardless of size and hardness with stone free increased rate, without discharge symptoms (renal colic, stein strasse) with rapid recovery of the renal functionality altered by obstruction; association with pyeloureteral junction modelling interventions, affordable equipment, reduced hospital costs. Complications are low, less serious and can be dealt mostly conservative. LITHIASIS